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Figure 2 | Genome Biology

Figure 2

From: Circular reasoning rather than cyclic expression

Figure 2

Expression values for MCM6 in humans, budding yeast, and fission yeast. Values are log ratios between synchronized and unsynchronized cells. (a, b) Expression profiles of budding yeast MCM6 under different cell-cycle arrest methods [2,3]. (c, d) Expression of fission yeast mcm6 under different arrest methods [4,5]. (e) Expression of MCM6 in human HeLa cells [7]. Cell-cycle stages are shown underneath each panel. Jensen et al. [14] claim that although human MCM6 is cycling at the transcriptional level, its homologs in budding yeast and fission yeast do not cycle. As (a-d) show, the expression of yeast MCM6 seems more cyclic than that of human MCM6, highlighting the limitations of species-by-species thresholding.

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