Skip to main content

Table 1 Human AID/APOBEC paralogs

From: The AID/APOBEC family of nucleic acid mutators

Name Genomic location Exons Deaminase domains Expression Cellular localization Editing activity Target References
AID 12p13 5 1 Activated B cells, Testis Mainly cytoplasmic, acts in the nucleus DNA Immunoglobulin gene [3,31]
APOBEC1 12p13.1 5 1 Small intestine Cytoplasmic/nuclear, acts in the nucleus RNA, DNA Apolipoprotein B mRNA [1,2]
APOBEC2 6p21 3 1 Skeletal muscle, heart Cytoplasmic/nuclear Unknown Unknown [15,16]
APOBEC3A 22q13.1 5 1 Keratinocytes, blood Cytoplasmic/nuclear DNA Adeno-associated virus, retrotransposons [4,104]
APOBEC3B 22q13.1 8 2 Intestine, uterus, mammary gland, keratinocytes, other Predominantly nuclear DNA Retroviruses, retrotransposons, HBV [4,104]
APOBEC3C 22q13.1 4 1 Many tissues Cytoplasmic/nuclear DNA Retroviruses, retrotransposons, HBV [4]
APOBEC3DE 22q13.1 7 2 Thyroid, spleen, blood Unknown DNA Retroviruses [4,10,107]
APOBEC3F 22q13.1 8 2 Many tissues Cytoplasmic DNA Retroviruses, retrotransposons, HBV [4]
APOBEC3G 22q13.1 8 2 Many tissues, T cells Cytoplasmic DNA Retroviruses, retrotransposons, HBV [4,5]
APOBEC3H 22q13.1 5 1 Blood, thymus, thyroid, placenta Unknown DNA Retroviruses [10,107]
LOC196469* 12q23 1 2 Pseudogene - - - [10,107]
APOBEC4 1q25.3 2 1 Testis Unknown Unknown Unknown [14]
  1. *This pseudogene originated from a recent retrotranspositional event. HBV, hepatitis B virus.