Figure 3

Snapshots of gene expression during the IDC. Expression ratios indicate early transcriptional activities at P. falciparum subtelomeres. Shown are two frames of an animation of expression levels detected on the chromosome loci during the IDC: (a) 10 hours and (b) 40 hours post-infection. Red dots indicate high and green dots low expression levels as determined by intensity ratios. Note the accumulation of highly expressed genes at the chromosomal ends. Upper left corner of each frame: 'infection timer' where the red and green curve represent the number of genes having their highest (red) or lowest (green) expression at the respective time (density curves over time of maxima/minima of all genes weighted by the gene intensity; see also Materials and methods).