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Table 1 Candidate genes whose expression is altered in the cancer stem cell population

From: Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions

Gene description Symbol Stem versus committed* Malignant versus benign*
Pregnancy-associated plasma protein A, pappalysin 1 PAPPA 3.83 3.26
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) NFKB1 2.30 1.86
Tight junction protein 2 (zona occludens 2) TJP2 2.51 1.72
Abl-interactor 1 ABI1 3.41 1.84
B-cell translocation gene 1, anti-proliferative BTG1 3.95 1.53
Interleukin 6 (interferon, beta 2) IL6 1.93 5.18
CASP8 and FADD-like apoptosis regulator CFLAR 1.90 1.41
Smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) SMU1 1.90 1.63
S100 calcium binding protein A3 S100A3 1.92 1.55
Chromosome 17 open reading frame 27 C17orf27 1.63 1.80
RAS and EF-hand domain containing RASEF 2.31 1.71
Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ITGAV 2.55 1.62
Interferon gamma receptor 1 IFNGR1 1.70 1.46
Insulin growth factor-like family member 1 IGFL1 -1.17 -28.61
Microseminoprotein, beta- (PSP94) MSMB -27.78 -2.84
Prostate stem cell antigen PSCA -20.11 -2.27
Carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM5 -19.12 -1.77
S100 calcium binding protein A7 (psoriasin 1) S100A7 -11.48 2.28
Hydroxyprostaglandin dehydrogenase 15-(NAD) HPGD -8.54 -2.41
Carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM7 -19.22 2.95
Trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) TFF1 -11.74 -2.25
Prolactin-induced protein PIP -17.42 1.04
  1. *Values are mean fold expression changes abstracted from Affymetrix datasets. Positive values (top half) indicate over expression in the cancer stem cell samples. Negative values (bottom half) indicate genes over-expressed in the committed cell or benign cell fractions.