Individual mRNA expression profiles reveal the effects of specific microRNAs

Table 1 Correlation between predicted and previously characterized tissue-specific miRNA expression

miRNAs	Brain	Heart	Kidney	Liver	Lung	Ovary	SM	Testes
let-7	*1,2,3	*1,2,3,4	*1,3,4,6	*2	*1,8	*	*1	*3,9
miR-1/206	2	*1,2,4,5	1	*2	1		1,5
miR-10			*4,6,7			*7
miR-101	*2		4	*1			*	9
miR-122a	3			*1,2,3				9
miR-124a	*1,2
miR-125	*1,2	*1,3,4	*1,4	1	*1,3	*
miR-128	*1,2		*		*1	*	*
miR-133	2,3	*1,2	1				*1,2
miR-136	2							*
miR-137	*1,2			*	*	*
miR-140	*		4
miR-144		2		*
miR-146	3	2,4	4		*	*
miR-15	*2,3	1,2,3	*4,6		*1,3	*		*3,9
miR-150			4			*
miR-153	*1,2	*	*	*
miR-190	1		*7
miR-193			1,7,4		1		*
miR-196	*	*	*1,4		3	*7	*	*
miR-199		4	4	1			*
miR-204							*	*
miR-24	2,3	*2	1,4,6		*1,8	*
miR-26	1,2,3	1,4	1,4,6	1,2	1		* 1
miR-27	*2,3	*2	*4,6		*1,8	*	*	*9
miR-29	*1,2	2,4	*4,6		1
miR-30	*1,2,3	*2,4	*1,4,6	*1,2	*1	*	*1	*9
miR-31	*
miR-326		*				*
miR-33			4				*	*
miR-330				*
miR-331	* 3		*	*	*3	*
miR-335								*
miR-34	3					*		*9
miR-365	3			*
miR-370			*	*	*	*		*
miR-375	*
miR-378	*			*			*
miR-448	*	*	*	*	*		*	*
miR-503	*3	3	3		3			3
miR-9	*1,2

All miRNAs for which expression of predicted target genes (according to TargetScan) was lower than expected in ≥ 1 tissue (p < 0.1) are listed and the tissues marked with an asterisk. Tissues in which miRNA expression has been experimentally characterized are indicated by the number of the appropriate reference: 1, Sempere et al. [29]; 2, Lagos-Quintana et al. [28]; 3, Gu J et al. [47]; 4, Naraba and Iwai [48]; 5, Zhao Y et al. [49]; 6, Lagos-Quintana et al. [50]; 7, Lagos-Quintana et al. [51]; 8, Hayashita et al. [52]; 9, Yu et al. [53]). Cells with both a reference number and asterisk indicate the overlap between our predicted expression pattern and the experimental data. SM, skeletal muscle.

ISSN: 1474-760X