Figure 7

Correlation between miRNAs with predicted effects on mRNA expression and miRNA expression levels detected by RT-PCR. miRNAs were divided into groups according to predicted target gene expression in human tissues, as described previously. The expression, as determined by RT-PCR [34] (y-axis), of the miRNAs in these groups (x-axis) is depicted by boxplots that illustrate the significantly higher expression (t-test, p ranging from 0.0014 in kidney to 0.0385 in brain) of miRNAs with low target gene expression relative to those with mid or high target expression (in all tissues except heart). Where necessary to present the median and interquartile ranges effectively, up to two outliers were omitted.