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Table 1 Estrogen-regulated probe sets that are differentially expressed in wounds from elderly compared to young subjects

From: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

Affy ID Gene* Gene (description) Function q-value FC
Down-regulated probe sets (65)      
   207720_at LOR loricrin Major cornified envelope protein 0 -235
   201909_at RPS4Y1 ribosomal protein S4, Y-linked 1 40S ribosomal component 0 -142
   215704_at FLG filaggrin Cornified envelope-keratin linker 9.4E-13 -114
   206177_s_at ARG1 arginase, liver Delayed healing-associated 9.2E-11 -82.0
   206643_at HAL histidine ammonia-lyase Histidine catabolism 1.5E-10 -59.0
   206421_s_at SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 Proteinase inhibitor for plasmin 5.9E-13 -47.6
   206192_at CDSN Corneodesmosin Desquamation/adhesion 2.5E-06 -30.1
   213796_at SPRR1A small proline-rich protein 1A Cornified envelope precursor protein 1.5E-05 -29.4
   207324_s_at DSC1 desmocollin 1 Desmosomal cadherin/adhesion 9.6E-06 -28.9
   209719_x_at SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 Inflammation and cancer-associated 1.6E-05 -22.4
   217496_s_at IDE insulin-degrading enzyme Wound fluid/resolution of insulin response 4.0E-06 -20.5
   211597_s_at HOP homeodomain-only protein Serum response factor binding 1.7E-04 -19.7
   211726_s_at FMO2 flavin containing monooxygenase 2 (non-functional) Non-functional oxidative enzyme 7.0E-04 -18.9
   220414_at CALML5 calmodulin-like 5 Epidermal-associated calcium-binding 2.0E-05 -17.7
   203328_x_at IDE insulin-degrading enzyme Wound fluid/resolution of insulin response 1.4E-05 -17.4
   210413_x_at SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 Cancer and inflammation-associated 3.1E-05 -15.8
   219795_at SLC6A14 solute carrier family 6 (amino acid transporter), member 14 Amino acid transport/obesity 6.9E-04 -15.6
   210074_at CTSL2 cathepsin L2 Lysosomal cysteine proteinase 3.8E-05 -15.5
   222242_s_at KLK5 kallikrein 5 Desquamation, angiogenesis and cancer 4.0E-05 -15.0
   201348_at GPX3 glutathione peroxidase 3 (plasma) Protection from oxidative damage 1.2E-05 -14.8
   202018_s_at LTF lactotransferrin Inflammatory-cell-derived antioxidant 4.6E-02 -14.5
   205185_at SPINK5 serine peptidase inhibitor, Kazal type 5 Anti-inflammatory/anti-microbial 3.8E-05 -14.4
   211906_s_at SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 Cancer and inflammation-associated 5.7E-05 -12.4
   219232_s_at EGLN3 egl nine homolog 3 (C. elegans) Hypoxia-inducible apoptosis-inducing 1.4E-05 -12.1
   213256_at MARCH3 membrane-associated ring finger (C3HC4) 3 Poorly characterized ubiquitin ligase 1.6E-05 -12.1
   204733_at KLK6 kallikrein 6 (neurosin, zyme) Hormone regulated serine protease 1.4E-05 -11.9
   202179_at BLMH bleomycin hydrolase Cysteine peptidase 2.1E-03 -11.8
   214549_x_at SPRR1A small proline-rich protein 1A Cornified envelope precursor protein 1.6E-04 -11.3
   207908_at KRT2 keratin 2 (epidermal ichthyosis bullosa of Siemens) Supra-basally expressed cytokeratin 1.2E-03 -11.1
   210338_s_at HSPA8 heat shock 70 kDa protein 8 ERalpha-inhibiting heat shock protein 9.9E-04 -10.6
   209720_s_at SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 Inflammation and cancer-associated 3.3E-04 -10.5
   201849_at BNIP3 BCL2/adenovirus E1B 19 kDa interacting protein 3 Mitochondrial apoptosis-inducing 2.7E-04 -10.1
   205916_at S100A7 S100 calcium binding protein A7 Chemotactic psoriasis-associated protein 1.7E-04 -10.0
   204952_at LYPD3 LY6/PLAUR domain containing 3 Upregulated in migrating keratinocytes 1.2E-03 -9.7
   206595_at CST6 cystatin E/M Cysteine protease inhibitor 1.7E-06 -9.3
   203327_at IDE insulin-degrading enzyme Wound fluid/resolution of insulin response 7.0E-04 -9.3
   209555_s_at CD36 CD36 molecule Thrombospondin receptor 4.0E-03 -9.2
   219532_at ELOVL4 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 Skin barrier-promoting fatty acid elongase 1.5E-05 -9.2
   209126_x_at KRT6B keratin 6B Injury-associated keratin 1.7E-03 -9.1
   212573_at ENDOD1 endonuclease domain containing 1 Unknown 8.3E-04 -9.0
   214599_at IVL involucrin Early cornified envelope protein 2.8E-03 -8.8
   209218_at SQLE squalene epoxidase Rate-limiting sterol biosynthesis enzyme 7.2E-04 -8.8
   207356_at DEFB4 defensin, beta 4 Antimicrobial peptide 6.0E-03 -8.8
   210138_at RGS20 regulator of G-protein signaling 20 GTPase-activating protein 8.1E-04 -8.7
   202504_at TRIM29 tripartite motif-containing 29 Cancer-associated transcription factor 2.2E-03 -8.6
   205016_at TGFA transforming growth factor, alpha IFN-induced/epidermal regeneration 1.0E-03 -8.5
   209309_at AZGP1 alpha-2-glycoprotein 1, zinc TNFA-regulated prostate-cancer marker 3.5E-04 -8.5
   209800_at KRT16 keratin 16 (focal non-epidermolytic palmoplantar keratoderma) Hyperproliferation and healing-associated keratin 1.2E-03 -8.3
   205778_at KLK7 kallikrein 7 (chymotryptic, stratum corneum) Innate immunity/desquamation 1.2E-05 -8.3
   219756_s_at POF1B premature ovarian failure, 1B Unknown 3.9E-05 -8.1
   214091_s_at GPX3 glutathione peroxidase 3 (plasma) Protection from oxidative damage 3.0E-03 -8.1
   203585_at ZNF185 zinc finger protein 185 (LIM domain) Actin-associated tumor suppressor 1.4E-03 -8.1
   206008_at TGM1 transglutaminase 1 CE formation/epidermal differentiation 4.6E-05 -8.0
   202037_s_at SFRP1 secreted frizzled-related protein 1 Repressor of WNT signaling 6.6E-04 -7.9
   202539_s_at HMGCR 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Rate-limiting cholesterol synthesis enzyme 7.4E-04 -7.8
   203575_at CSNK2A2 casein kinase 2, alpha prime polypeptide p53 phosphorylation, WNT signaling 4.6E-04 -7.7
   206884_s_at SCEL sciellin Cornified envelope precursor protein 2.1E-04 -7.5
   204284_at PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C Regulates a wide variety of cellular functions 9.9E-04 -7.4
   266_s_at CD24 CD24 molecule Marker for epithelial neoplasms 2.7E-04 -7.4
   203914_x_at HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Main enzyme for prostaglandin degradation 1.6E-04 -7.3
   219410_at TMEM45A transmembrane protein 45A Hox-regulated/reproductive tissue expressed 8.1E-04 -7.3
   206488_s_at CD36 CD36 molecule Thrombospondin receptor 1.2E-05 -7.3
   204881_s_at UGCG UDP-glucose ceramide glucosyltransferase Keratinocyte glucosyltransferase 1.8E-03 -7.1
   213933_at PTGER3 prostaglandin E receptor 3 (subtype EP3) Impaired wound healing in null mouse 8.3E-04 -7.1
   216379_x_at CD24 CD24 molecule Marker for epithelial neoplasms 7.9E-04 -7.0
Up-regulated probe sets (8)      
   221728_x_at XIST X (inactive)-specific transcript X chromosome inactivation 2.4E-12 191.8
   214218_s_at XIST X (inactive)-specific transcript X chromosome inactivation 1.0E-09 56.2
   206211_at SELE selectin E (endothelial adhesion molecule 1) Endothelial-leukocyte adhesion 9.0E-02 8.5
   211600_at PTPRO protein tyrosine phosphatase, receptor type, O New marker of podocyte injury 5.0E-04 8.4
   220940_at KIAA1641 KIAA1641 Unknown 1.0E-04 8.3
   203915_at CXCL9 chemokine (C-X-C motif) ligand 9 Interferon induced, TH1 response 6.3E-02 7.3
   204324_s_at GOLPH4 golgi phosphoprotein 4 Protein export 8.3E-04 7.3
   201205_at RRBP1 ribosome binding protein 1 homolog 180 kDa (dog) Developmentally regulated extracellular matrix glycoprotein 6.3E-03 7.3
  1. *Genes in bold have been validated by qPCR. CyberT-derived multiple testing corrected q-value. Fold change (old/young).