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Table 1 Characteristics of Sme efflux transporters in S. maltophilia K279a

From: The complete genome, comparative and functional analysis of Stenotrophomonas maltophiliareveals an organism heavily shielded by drug resistance determinants

Systematic ID Name Known or putative regulation mechanism Closest match to a known antimicrobial efflux protein
Smlt4474-4476 SmeABC Two component regulator (SmeSR, Smlt4477-8) S. maltophilia SmeABC [20]
Smlt4070-4072 SmeDEF Tet-R type (SmeT, Smlt4073) S. maltophilia SmeDEF [17,22]
Smlt1829-1833 SmeVWX LysR type (Smlt1827) 51%, 56% and 48% amino acid identity, respectively, to P. aeruginosa MexEF-OprN [64]
Smlt2201-2202 SmeYZ Two component regulator (Smlt2199-30) 44% and 59% amino acid identity, respectively, to AdeAB of A. baumanii [65]
Smlt3170-3171 SmeGH TetR type (Smlt3169) 39% and 49% amino acid identity, respectively, to AcrAB of M. morganii [66]
Smlt3788-3787 SmeMN ? <30% identity to other known antimicrobial efflux proteins
Smlt3925-3924 SmeOP TetR type (Smlt3926) <30% identity to other known antimicrobial efflux proteins
Smlt4279/4281 SmeIJK ? 41%, 50% and 44% amino acid identity, respectively, to MtdABC of E. coli [25]