Gene-to-metabolite correlation network analyses. (a) Substructure extracted from Adp correlation network with MCODE algorithm, showing preferentially linked functionally related metabolites. The m/z values of selective ions used for quantification are shown in parentheses for each metabolite. In the box and whisker plots of the metabolites 1 and 3 represent MG and DH lines (ancestors), and 2 and 4 represent MGAdp and DHAdp lines (evolved). (b-g) Topologic properties of all evolution-specific coexpression networks. Panel b shows the degree distribution of the clustering coefficients of all of the evolution-specific network entities. The average clustering coefficient of all the nodes was plotted against the number of neighbours. Panel c shows the degree distribution of the networks; the number of nodes with a given degree (k) in the networks approximates a power law (P [k] about kγ ; Adp γ = 1.70, AdpGal γ = 1.76, and Stat γ = 1.32). Distribution of the shortest path between pairs of nodes in the evolution specific (panels d and e) and intersection (panels f and g) networks; constructed with principal components analysis thresholds of 0.8 (panels d and f) and 0.9 (panels e and g).