Figure 7

Disease-related genes are under stronger selective pressure. Disease related genes were obtained from CGC (243 genes), COSMIC (3,103 genes), and OMIM (2,334 genes) databases. The SNP A/S ratio was calculated for each group. The 95th percentile confidence intervals from bootstrap resampling (shown as error bars) are [0.19, 0.27] for CGC, [0.20, 0.22] for COSMIC, [0.23, 0.26] for OMIM, and [0.31, 0.33] for others.