Subnetworksa | Nickel | Cadmium | ||
---|---|---|---|---|
 | Interacting gene products | Functionally linked gene productsb | Interacting gene products3 | Functionally linked gene productsb,c |
V-ATPase assembly/regulation (sn. 1) | Rav1, Vma16, Vph1 | Â | Â | Â |
Proteasome (sn. 3) | Cue1 | Â | Bre5, Cdc26, Doa1, Hlj1, Sel1, Ubi4, Ubp6, Ump1 | Dia2 |
Chromatin assembly/remodelling (sn. 4) | Â | Â | SAGA complex (Ada2, Chd1, Gcn5, Hfi1, Ngg1, Spt7*, Spt20); Ino80 complex (Arp5, Arp8, Taf14); COMPASS complex (Bre2, Sdc1); Asf1, Ard1, Eaf7*, Esc2, Hda1*, Hmo1, Ioc2 | Hmo1 |
Cell wall integrity pathway (sn. 5) | Â | Whi3 | Bem2, Dom34, Ecm33, Kcs1, Pin4, Pog1, Rvs161, Rvs167, Sic1, Sit4*, Sur7, Swi4, Swi6, Whi2 | Â |
CCR4 and other mRNA processing enzymes (sn. 6) | Â | Â | Dhh1 | Paf1 |
Nuclear pore complex (sn. 7) | Nup84, Sac3, Thp1 | Â | Â | Â |
Essential ion homeostasis (sn. 9) | Pho88 | Ccc2, Zap1 | Smf3 | Gef1, Pho89 |
AP-3 complex (sn. 10) | Apl5, Apl6, Apm3, Aps3 | Â | Â | Â |
General transcription (sn. 11) | Mft1, Rpb9, Rtt103, Thp2 | Â | Mediator complexes (Gal11, Med2, Pgd1, Spt21, Srb8*, Srb10); Cad1, Elp4, Tup1, Yap1 | Mss11 |
DNA repair (sn. 12) | Â | Â | Ctf4, Him1, Met18, Mms22, Mre11, Pol32, Rad6, Rad27, Xrs2 | Â |
Antioxidant defense (sn. 13) | Â | Â | Atx2, Ccs1, Sod1, Sod2 | Cad1, Glr1, Gsh1, Gsh2, Yap1, Zwf1 |
Hog1 pathway (sn. 14) | Â | Â | Fps1, Hog1, Pbs2, Rck2, Ste11 | Gre2 |
Vesicle targeting to, from or within Golgi (sn. 15) | Â | Â | Erv41, Erv46, Get2, Sac1, Sec22, Sec66; Vps13; Cog5, Cog8; Pep7, Tlg2, Vps3, Vps9, Vps21, Vps45; Arl1, Arl3, Ent3, Gga2, Nhx1*, Rgp1, Ric1, Sys1, Yil039w*, Vps51, Vps54, Ypt6; Vam10*, Vps1*, Vps8*; Pep8*, Vps5*, Vps17*, Vps29*, Vps30*, Vps35*, Vps38* | Apm2, Snx3* |
Ubiquitin-dependent sorting to the multivesicular body pathway (sn. 16) | Â | Â | Vps27*; ESCRT I complex (Vps28*, Mvb12*, Srn2*, Stp22*); ESCRT II complex (Snf8*, Vps25*, Vps36*); ESCRT-III complex (Did4*, Snf7*, Vps20*, Vps24*); Bro1*, Did2*, Doa4*, Vps4* | Bsd2*, Bul1*, Nhx1*, Tre1* |