Figure 1

Distribution among different sensitivity/resistance groups and functional classification of metal tolerance affecting mutations. (a) Venn diagram visualization of mutant strains displaying multimetal or metal-specific sensitivity (green circles) or resistance (red circles); also shown are mutants characterized by an opposite phenotypic response to the two metals (45 cadmium sensitive/nickel resistant strains and one cadmium resistant/nickel sensitive strain). (b) Biologic processes associated with metal toxicity-modulating genes identified with the Gene Ontology (GO) Term Finder program [99]. Statistical significance of GO term/gene group association (P-value < 0.001) and enrichment ratios are reported for each category; parent terms are presented in bold, and child terms of the parent class 'transport' are presented in italics.