Skip to main content

Table 4 Transcriptional regulatory global models constructed for the ten microarray clusters

From: ModuleMiner - improved computational detection of cis-regulatory modules: are there different modes of gene regulation in embryonic development and adult tissues?

Cluster Key transcription factors and binding sites in TRGM (weight)
Protein synthesis NF-Y (1.59), DEC (1.13), HIC1 (1.09), general initiator sequence (0.47), CCAAT box (0.44), TCF-4 (0.32)
Oocyte/fertilized egg T3R (1.00), NF-Y (1.00), ETS/PEA3 (0.99), MAZ (0.92), AP2α (0.78), SP1 (0.30)
Neural tissues UF1-H3β (1.13), CRE-BP/CJUN/ATF-1 (1.00), AP-2 (0.87), ETF (0.55), AP-1/NF-E2 (0.33)
Lymphocytes STAT6 (1.00), PU.1 (0.99), ETS (0.96), STAT5/STAT (0.95), SP1 (0.89)
Testis/spermatogenesis -
Liver TCF1/HNF-1 (1.00), NF-1 (1.00), C/EBP (0.99), HNF-4/COUP (0.99), PPAR/HNF-4/COUP/RAR (0.66), MYC-MAX (0.58), PPAR (0.33)
Mitochondrion c-ETS (1.35), VDR (1.00), GATA-1/GATA-2 (1.00), ZID (0.82), AR (0.43), ROAZ (0.34)
Extracellular matrix AP-1/NF-E2/BACH1 (2.00), FOXD1 (1.00), BLIMP1 (1.00), SRF (0.70), MEF-2/RSRFC4 (0.51), STAT5/STAT6 (0.35)
Cardiac muscle SP-3 (1.00), myogenin (1.00), MEF2A (1.00), SRF (1.00), tyroid hormone receptor/RAR/RXR (0.91), muscle TATA box (0.48)
Energy metabolism CREB/ATF/HLF (1.01), WHN (1.00), SPIB (0.71), PPARγ/RXRα (0.65), general initiator sequence (0.51), RFX (0.31)
  1. TRGM, transcriptional regulatory global model.