Table 4 Transcriptional regulatory global models constructed for the ten microarray clusters
Cluster | Key transcription factors and binding sites in TRGM (weight) |
|---|---|
Protein synthesis | NF-Y (1.59), DEC (1.13), HIC1 (1.09), general initiator sequence (0.47), CCAAT box (0.44), TCF-4 (0.32) |
Oocyte/fertilized egg | T3R (1.00), NF-Y (1.00), ETS/PEA3 (0.99), MAZ (0.92), AP2α (0.78), SP1 (0.30) |
Neural tissues | UF1-H3β (1.13), CRE-BP/CJUN/ATF-1 (1.00), AP-2 (0.87), ETF (0.55), AP-1/NF-E2 (0.33) |
Lymphocytes | STAT6 (1.00), PU.1 (0.99), ETS (0.96), STAT5/STAT (0.95), SP1 (0.89) |
Testis/spermatogenesis | - |
Liver | TCF1/HNF-1 (1.00), NF-1 (1.00), C/EBP (0.99), HNF-4/COUP (0.99), PPAR/HNF-4/COUP/RAR (0.66), MYC-MAX (0.58), PPAR (0.33) |
Mitochondrion | c-ETS (1.35), VDR (1.00), GATA-1/GATA-2 (1.00), ZID (0.82), AR (0.43), ROAZ (0.34) |
Extracellular matrix | AP-1/NF-E2/BACH1 (2.00), FOXD1 (1.00), BLIMP1 (1.00), SRF (0.70), MEF-2/RSRFC4 (0.51), STAT5/STAT6 (0.35) |
Cardiac muscle | SP-3 (1.00), myogenin (1.00), MEF2A (1.00), SRF (1.00), tyroid hormone receptor/RAR/RXR (0.91), muscle TATA box (0.48) |
Energy metabolism | CREB/ATF/HLF (1.01), WHN (1.00), SPIB (0.71), PPARγ/RXRα (0.65), general initiator sequence (0.51), RFX (0.31) |