Figure 6From: Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysisHistone modification changes and RNA polymerase (Pol) II levels on gene promoters during TSA treatment and EB formation. Histone modifications (H3 acetylation (acH3), and lysine 4 (3mK4) and lysine 27 (3mK27) trimethylation) and Pol II levels on the promoters of (a) activated genes (Pdgfrβ, Mlf1, Hoxa1) and (b) repressed genes (Nanog, Nr0b1, Sall1) during TSA treatment (left) or EB differentiation (right). Modification levels were estimated using ChIP assays. Results are expressed as percent of the input chromatin.Back to article page