NF-κB target genes were reverse-engineered and assigned to signaling pathways with significant implication in the malignant phenotype. NF-κB target genes were analyzed by IPA and the pathways with statistical significance were presented. The y-axis represents the statistical significances in log scale of each signaling pathway, and the x-axis indicates the predicted genes specifically regulated by NF-κB subunits. On the x-axis, 'NF-κB' refers to common NF-κB regulation (not subunit specific), and 'RELA' and 'NFκB1' refer to regulation by RELA or NFκB1 subunits, respectively. (a) Pathways associated with up-regulated genes in cancer cells with different p53 statuses; (b) pathways associated with down-regulated genes. *Pathways that reached a statistically significant level (P < 0.05).