RELA or NFκB1 dominant networks revealed by IPA. (a, b) RELA or (c, d) NFκB1 dominant networks in cells with wild-type p53-deficient (a, c) or mutant p53 (b, d) status were generated by IPA and showed graphically. The brightness of node colors is proportional to the fold changes of gene expression levels. Color indicates up-regulated (red) and down-regulated (green) genes. Blue lines indicate direct connections of RELA or NFκB1 with genes through different functionalities.