Table 6 Identical sequences of FL8 present across multiple clusters with GO MF propensity calculated using level 3*
PDB [reference]†| Molecule | Putative fragment function | Sequence (propensity)§ | P-value |
|---|---|---|---|---|
1u19A‡ [53] | Rhodopsin | Part of extracellular domain intradiskal loop involved in cell signaling | 11: VPFSNKTG (47) | 0.02 |
1edsA [54] | Bovine rhodopsin | Same as above | 17: GCNLEGFF (93) | 0.01 |
| Â | Â | Â | 21: EGFFATLG (39) | 0.03 |
| Â | Â | Â | 22: GFFATLGG (130) | 0.008 |
1edvA [54] | Bovine rhodopsin | Same as above | 16: CGIDYYTPP (96) | 0.01 |
1edxA [54] | Bovine rhodopsin | Same as above | 11: VPFSNKTG (22) | 0.04 |
1tgj‡ [45] | Human transforming growth factor β3 | Structure destabilized on dislufide bond reduction | 72: ASASPCCV (157) | 0.006 |
1kl9A‡ [55] | Human translation initiation factor 2α | Linker for the penultimate 310 helix and the last α-helix in domain 1 | 163: DSLDLNED (35) | 0.03 |
| Â | Â | Â | 164: SLDLNEDE (35) | 0.003 |
1q9bA‡ [56] | Hevein (IgE bonding natural allergen) | Part of conformational epitope | 6: QAGGKLCP (62) | 1.3e-08 |
| Â | Â | Â | 8: GGKLCPNN (299) | 2.3e-08 |
| Â | Â | Â | 9: GGLCPNNL (123) | 9.8e-12 |
| Â | Â | Â | 11: LCPNNLCC (25) | 1.3e-06 |
| Â | Â | Â | 12: CPNNLCCS (28) | 2.0e-08 |
|  |  |  | 14: NNLCCSQW (28) | ≈ 0 |
| Â | Â | Â | 15: NLCCSQWG (79) | 1.5e-08 |
1wpgA‡ [57] | Sarcoplasmic/endoplasmic reticulum calcium ATPase | Phosphorylation of D351 causes the protein to switch conformation | 349: CSDKTGTL (41) | 0.002 |
| Â | Â | Â | 350: SDKTGTLT (56) | 0.001 |
1mhsA‡ [58] | Proton ATPase | Phosphorylation of D378 causes the protein to switch conformation | 631: MTGDGVND (22) | 0.008 |
| Â | Â | Â | 633: GDGVNDAP (25) | 0.04 |
| Â | Â | Â | 376: CSDKTGTL (41) | 0.002 |
| Â | Â | Â | 377: SDKTGTLT (56) | 0.001 |