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Table 4 Details of representative functionally important fragments of FL8 enumerated using GO level 3

From: Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments

PDB (group number)* GO MF (EC number) PROSITE pattern Molecular function Functionally important fragment(s) (start: sequence (propensity)) P-value
1df9A (1) 0003724 (3.4.21.91) - Dengue virus NS3 protease 132: PGTSGSPI (30) 4.17e-5
     133: GTSGSPII (40) 5.95e-8
     156: TRSGAYVS (24) 0.007
1e7uA (2) 0016773 (2.7.1.153) PS00915 Phosphatidyl-inositol 3- and 4-kinase signatures 1 and 2 857: TESLDLCL (48) 0.02
   PS00916   861: DLCLLPYG (23) 0.04
     872: TGDKIGMI (29) 0.03
1tgj (3/4) 0005160 PS00250 Cytokines (repair of tissue) 27: DLGWKWVH (305) 0.04
  1. *The chain identifier is given after the four letter PDB code, wherever present. Amino acids in bold either directly or indirectly participate in the enzyme function. PROSITE pattern: (33-48, VHEPKGYYANFCSGPC).