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Table 4 Details of representative functionally important fragments of FL8 enumerated using GO level 3

From: Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments

PDB (group number)*

GO MF (EC number)

PROSITE pattern

Molecular function

Functionally important fragment(s) (start: sequence (propensity))†

P-value

1df9A (1)

0003724 (3.4.21.91)

-

Dengue virus NS3 protease

132: PGTSGSPI (30)

4.17e-5

    

133: GTSGSPII (40)

5.95e-8

    

156: TRSGAYVS (24)

0.007

1e7uA (2)

0016773 (2.7.1.153)

PS00915

Phosphatidyl-inositol 3- and 4-kinase signatures 1 and 2

857: TESLDLCL (48)

0.02

  

PS00916

 

861: DLCLLPYG (23)

0.04

    

872: TGDKIGMI (29)

0.03

1tgj (3/4)

0005160

PS00250‡

Cytokines (repair of tissue)

27: DLGWKWVH (305)

0.04

  1. *The chain identifier is given after the four letter PDB code, wherever present. †Amino acids in bold either directly or indirectly participate in the enzyme function. ‡PROSITE pattern: (33-48, VHEPKGYYANFCSGPC).