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Table 3 Details of arbitrarily chosen FL8 fragments with propensity ≥20 mapped from GO propensity calculations at level 3

From: Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments

GO MF Propensity PDB entry [reference]* Start Functional description P-value
0004016 1,816 1azsA [34] 489 VC1 and IIC2 domain interface 0.0006
0019210 1,450 1jsuC [35] 61 Highly conserved β hairpin from p27 interacting with Cdk2 and inhibiting the cyclin-Cdk2 complex 0.0007
0000036 685 1t8kA [33] 19 Part of ligand binding region 0.0014
0016638 450 2bbkL [36] 48 Involved in protein-protein interactions 0.002
0042030 395 1n7lA [32] 13 Important loop connects two helices 0.002
0016566 382 1dvoA [31] 148 Part of large negatively charged region for RNA binding 0.003
0004016 168 1azsA [34] 501 Part of binding pocket of FKP 0.006
0004879 149 1ie9A [37] 288 Forms part of active site pocket 0.007
0016813 137 1wohA [30] 272 One of the active site residues is present 0.007
0016247 107 1oaw [38] 30 Conserved cysteines are present 0.009
0004930 98 1ijyA [29] 113 Surface exposed loop with conserved 'WP' sequence 0.01
0004383 92 1xbnA [39] 74 Forms part of HEM binding pocket 0.01
0005158 61 1qqgB [40] 56 Part of a cationic cluster§ 0.02
0008428 61 1b2uD [41] 39 Interact with the active site residues 0.02
0003724 26 1fukA [42] 341 Conserved interaction with DEAD box motif 0.04
  1. *These proteins do not have a PROSITE sequence signature. The chain identifier is given after the four letter PDB code, wherever present. Residue number as given in PDB. Only PROSITE domain signature exists: 391-518. §Only PROSITE domain signature exists: 12-114.