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Table 5 Predicted mediator transcription factors of PML-RARα

From: Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Gene ID

Symbol

Gene name

APL expression

SAM score

12053

Bcl6

B-cell leukemia/lymphoma 6

Down

-7.39

21429

Ubtf

upstream binding transcription factor, RNA polymerase I

Up

4.49

56070

Tcerg1

transcription elongation regulator 1 (CA150)

Up

6.25

56463

Snd1

expressed sequence AL033314

Up

4.44

71458

Bcor

Bcl6 interacting corepressor

Up

4.90

109151

Chd9

chromodomain helicase DNA binding protein 9

Up

5.64

  1. SAM and the binding profiles of Rara and PML-RARα were used to identify direct regulatory targets of PML-RARα. These six TFs may activate the dysregulation of other aberrantly expressed TFs in APL.