Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Table 2 Transcription factor genes identified in coexpressed gene clusters

Cluster	Gene ID	Symbol	Expression correlation coefficient	Association with myeloid development	Reference
UP0	13653	Egr1	0.9928	Stimulates development of hematopoietic progenitor cells	[35]
	13654	Egr2	0.9459
	14013	Evi1	0.9373	Involved in many myeloid disorders	[76]
	14281	Fos	0.9488	Modulates myeloid cell survival and differentiation	[42]
	16842	Lef1	0.9325	Expression altered in acute leukemia	[77]
	17131	Smad7	0.9041	Alters cell fate decisions of human hematopoietic repopulating cells	[78]
	18109	Mycn	0.9094
	19883	Rora	0.9335
	20849	Stat4	0.9562	Expressed in early myeloid development	[79]
	21414	Tcf7	0.9614
	56458	Foxo1	0.9575	Activates the mixed lineage leukemia gene	[80]
UP01	14013	Evi1	0.9042	Involved in many myeloid disorders	[76]
	14391	Gabpb1	0.9377	Activates the neutrophil elastase promoter	[81]
	16842	Lef1	0.9593	Expression altered in acute leukemia	[77]
	18044	Nfya	0.9036
	18109	Mycn	0.9509
	19883	Rora	0.9525
	217082	Hlf	0.9537	E2A-HLF fusion abrogates apoptosis in leukemia cells	[82]
UP67	12013	Bach1	0.9274
	17119	Mxd1	0.9168	Expression induced during myeloid development	[83]
	328572	Ep300	0.9097	Regulates Runx1 through acetylation of lysine residues	[84]

These TFs were all upregulated on just one day or over two consecutive days during the seven-day in vitro myeloid differentiation. Twelve of these seventeen TF genes aare known to regulate myeloid differentiation or be involved in myeloid leukemia.

ISSN: 1474-760X