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Table 1 Additional myeloid transcription factors identified by PAP

From: Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Cluster

Accession

TF

Symbol

Association with myeloid development

Reference

UP0

MA0081

SPI-B

Spib

Can functionally replace PU.1 in myeloid development

[85]

 

M00961

VDR

Vdr

Involved in monocytic differentiation in human leukemia cells

[86]

 

M00777

STAT

Stat4

Expressed in early myeloid development

[79]

 

MA0103

deltaEF1

Zfhz1a

  
 

M00655

PEA3

Etv4

  

UP1

M00161

Oct-1

Pou2f1

Regulates PU.1

[87]

UP7

M00658

PU.1

Sfpi1

Known regulator of hematopoiesis

[88]

 

M00329

Pax-9

Pax9

  
 

M00925

AP-1

Jun

Known regulator of myeloid development

[89]

 

M01031

HNF4

Hnf4a

  
 

MA0081

SPI-B

Spib

Can functionally replace PU.1 in myeloid development

[85]

UP01

M00217

USF

Usf1

Regulates HOXB4 in normal and leukemia stem cells

[90]

 

M00792

SMAD

Smad1

  
 

M00805

LEF1

Lef1

Expression altered in acute leukemia

[77]

 

M00799

Myc

Myc

Upregulated in AML and induces AML

[91]

 

MA0002

AML-1

Runx1

Known regulator of hematopoiesis

[88]

UP67

M00133

Tst-1

Pou3f1

  
 

M00188

AP-1

Jun

Known regulator of myeloid development

[89]

 

M00729

Cdx-2

Cdx2

Involved in the ETV6-CDX2 fusion protein

[92]

 

M00912

C/EBP

Cebpa

Known regulator of hematopoiesis

[88]

 

M00162

Oct-1

Pou2f1

Regulates PU.1

[87]

  1. PAP was used to identify overrepresented TF binding sites in each coexpressed gene clusrer. Almost all of these TFs are associated with myeloid development or myeloid leukemia.