Cluster | Accession | TF | Symbol | Association with myeloid development | Reference |
---|---|---|---|---|---|
UP0 | MA0081 | SPI-B | Spib | Can functionally replace PU.1 in myeloid development | [85] |
 | M00961 | VDR | Vdr | Involved in monocytic differentiation in human leukemia cells | [86] |
 | M00777 | STAT | Stat4 | Expressed in early myeloid development | [79] |
 | MA0103 | deltaEF1 | Zfhz1a |  |  |
 | M00655 | PEA3 | Etv4 |  |  |
UP1 | M00161 | Oct-1 | Pou2f1 | Regulates PU.1 | [87] |
UP7 | M00658 | PU.1 | Sfpi1 | Known regulator of hematopoiesis | [88] |
 | M00329 | Pax-9 | Pax9 |  |  |
 | M00925 | AP-1 | Jun | Known regulator of myeloid development | [89] |
 | M01031 | HNF4 | Hnf4a |  |  |
 | MA0081 | SPI-B | Spib | Can functionally replace PU.1 in myeloid development | [85] |
UP01 | M00217 | USF | Usf1 | Regulates HOXB4 in normal and leukemia stem cells | [90] |
 | M00792 | SMAD | Smad1 |  |  |
 | M00805 | LEF1 | Lef1 | Expression altered in acute leukemia | [77] |
 | M00799 | Myc | Myc | Upregulated in AML and induces AML | [91] |
 | MA0002 | AML-1 | Runx1 | Known regulator of hematopoiesis | [88] |
UP67 | M00133 | Tst-1 | Pou3f1 | Â | Â |
 | M00188 | AP-1 | Jun | Known regulator of myeloid development | [89] |
 | M00729 | Cdx-2 | Cdx2 | Involved in the ETV6-CDX2 fusion protein | [92] |
 | M00912 | C/EBP | Cebpa | Known regulator of hematopoiesis | [88] |
 | M00162 | Oct-1 | Pou2f1 | Regulates PU.1 | [87] |