Figure 4

Genetic networks operating in myeloid development and APL. In these networks, circle nodes represent TF genes. Genes that do not encode TFs are shown in rectangles. An arrow is drawn from TF-A to gene-B if TF-A regulates gene-B. (a) The predicted genetic network operating in myeloid differentiation. Multiple regulatory pathways in this network converge on one single TF, Rora. The expression profiles of the TF genes are color coded: blue, upregulated at day 0; yellow, upregulated at day 0 and day 1; purple, upregulated at day 7. (b) The seven TFs that are dysregulated in APL may be connected to form a common regulatory pathway. Aberrant expressions of these TFs are color coded: red, overexpression; green, underexpression. (c) The perturbation of the normal network by dysregulated TFs in APL. The normal and disease regulatory pathways converge on Rora and Rxra, respectively. The dysregulated pathway in APL may perturb the normal genetic network through Fos. Furthermore, many TFs in the normal network (shown in orange nodes) are predicted as direct targets of at least one TF dysregulated in APL (Table 4).