From: Proteomic analysis of the secretome of Leishmania donovani
GeneDB accession numbers | Protein identificationa | Mean Cm/CA ratiob | Putative functionc |
---|---|---|---|
Signal transduction proteins | |||
   LmjF35.2420 | Phosphoinositide-binding protein, putative | 3.51 | Kinased |
   LmjF33.1380 | Mitogen-activated protein kinase 11, putative, MAP kinase, putative | 2.42 | Kinase |
   LmjF09.0770 | Oligopeptidase b, serine peptidase, clan SC, family S9A-like protein | 2.31 | Cell-cell signaling |
   LmjF34.2820 | Regulatory subunit of protein kinase a-like protein | 2.30 | Kinase |
   LmjF28.2740 | Activated protein kinase c receptor (LACK) | 2.28 | Kinase receptor |
   LmjF25.0750 | Protein phosphatase, putative | 2.27 | Phosphatase |
   LmjF35.1010 | Casein kinase, putative | 2.08 | Kinase |
   LmjF10.0490 | Mitogen-activated protein kinase 3, putative, MAP kinase 3, putative | 1.73 | Kinase, signal transduction |
   LmjF31.2790 | ADP-ribosylation factor, putative | 1.67 | Small GTPase mediated signal transduction |
Immunosupressive proteins | |||
   LmjF35.2210 | Kinetoplastid membrane protein-11 | 2.33 | Immunosuppressive [51] |
   LmjF33.1750 | Macrophage migration inhibitory factor-like protein | 2.21 | Immunosuppressive [52] |
   LmjF25.0910 | Cyclophilin a | 1.73 | Immunosuppressive [103] |
Proteins Involved in Intracellular survival | |||
   LmjF14.1360 | Myo-inositol-1-phosphate synthase | 3.93 | Inositol biosynthesis [50] |
   LmjF23.0200 | Endoribonuclease L-PSP (pb5), putative | 3.91 | mRNA salvage, inhibition protein synthesis |
   LmjF11.0630 | Aminopeptidase, putative, metallo-peptidase, clan MF, family M17 | 3.05 | Proteolysis |
   LmjF28.1730 | Proteasome regulatory non-ATP-ase subunit 2, putative | 2.40 | Proteolysis |
   LmjF34.1040 | Uracil phosphoribosyltransferase, putative | 2.34 | Pyrimidine salvage |
   LmjF09.0770 | Oligopeptidase b, serine peptidase, clan SC, family S9A-like protein | 2.31 | Invasion, proteolysis |
   LmjF32.1820 | Iron superoxide dismutase, putative | 2.29 | Antioxidant |
   LmjF13.0090 | Carboxypeptidase, putative, metallo-peptidase, clan MA(E), family 32 | 2.14 | Proteolysis |
   LmjF28.2770 | Heat-shock protein hsp70, putative | 2.14 | Protein stability |
   LmjF26.1570 | Thimet oligopeptidase, putative, metallo-peptidase, clan MA(E), family M3 | 2.10 | Proteolysis |
   LmjF05.0960 | Dipeptidyl-peptidase III, putative, metallo-peptidase, clan M-, family M49 | 2.08 | Proteolysis |
   LmjF14.1160 | Enolase | 2.05 | Plasminogen binding [104], Invasion |
   LmjF19.0160 | Aminopeptidase, putative, metallo-peptidase, clan MG, family M24 | 2.04 | Proteolysis |
   LmjF21.1830 | Proteasome alpha 5 subunit, putative | 2.03 | Proteolysis |
   LmjF05.0350 | Trypanothione reductase | 1.99 | Antioxidant |
   LmjF21.0760 | Proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit | 1.97 | Proteolysis |
   LmjF23.0270 | Pteridine reductase 1 | 1.92 | Antioxidant |
   LmjF26.0810 | Glutathione peroxidase-like protein, putative | 1.89 | Antioxidant |
   LmjF27.0190 | Proteasome alpha 7 subunit, putative | 1.89 | Proteolysis |
   LmjF26.2280 | Nitrilase, putative | 1.86 | Carbon-nitrogen hydrolase |
   LmjF26.1240 | Heat shock protein 70-related protein | 1.86 | Protein stability |
   LmjF31.1890 | Peptidase m20/m25/m40 family-like protein | 1.85 | Proteolysis |
   LmjF06.0140 | Proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 1.85 | Proteolysis |
   LmjF29.0120 | Proteasome regulatory non-ATPase subunit, putative | 1.81 | Proteolysis |
   LmjF34.0650 | Proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, metallo-peptidase, Clan MP, Family M67 | 1.79 | Proteolysis |
   LmjF35.0750 | Proteasome activator protein pa26, putative | 1.78 | Proteolysis |
   LmjF35.2350 | Aminopeptidase P, putative, metallo-peptidase, clan MG, family M24 | 1.77 | Proteolysis |
   LmjF02.0370 | Proteasome regulatory non-ATPase subunit 6, putative | 1.77 | Proteolysis |
   LmjF36.3210 | 14-3-3 protein-like protein | 1.74 | Anti-apoptotic |
   LmjF21.1700 | Proteasome alpha 2 subunit, putative | 1.66 | Proteolysis |
   LmjF36.1600 | Proteasome alpha 1 subunit, putative | 1.64 | Proteolysis |
   LmjF35.4850 | Proteasome alpha 1 subunit, putative | 1.60 | Proteolysis |
Proteins involved in vesicular transport processes | |||
   LmjF35.2420 | Phosphoinositide-binding protein, putative (sorting nexin 4) | 3.51 | Transport of proteins and other substances |
   LmjF27.0760 | Small GTP-binding protein Rab1, putative | 2.27 | Endosomes/Golgi trafficking |
   LmjF32.1730 | Coatomer epsilon subunit, putative | 2.09 | Intracellular protein transport |
   LmjF36.1630 | Clathrin heavy chain, putative | 1.98 | Endocytosis, trans-Golgi to lysosome trafficking |
   LmjF18.0700 | Hypothetical protein, conserved | 1.85 | HEAT repeat, intracellular protein transport |
   LmjF31.2790 | ADP-ribosylation factor, putative | 1.67 | Intracellular protein transport |