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Table 1 Leishmania-secreted proteins associated with exosome-like and glycosomal vesicles

From: Proteomic analysis of the secretome of Leishmania donovani

GeneDB accession number Protein identificationa Mean Cm/CA ratio Microvesicle association
LmjF35.3340 6-Phosphogluconate dehydrogenase, decarboxylating, putative 3.01 GLY
LmjF29.0510 Cofilin-like protein 2.80 DC
LmjF36.6910 Chaperonin, putative, T-complex protein 1 (theta subunit), putative 2.61 AP
LmjF01.0770 Eukaryotic initiation factor 4a, putative 2.60 DC
LmjF28.2860 Cytosolic malate dehydrogenase, putative 2.20 AP
LmjF24.2060 Transketolase, putative 2.19 GLY
LmjF33.2550 Isocitrate dehydrogenase, putative 2.16 AP
LmjF28.2770 Heat-shock protein hsp70, putative 2.14 BC, DC, AP
LmjF35.3860 T-complex protein 1, eta subunit, putative 2.14 AP
LmjF12.0250 Cysteinyl-tRNA synthetase, putative 2.07 GLY
LmjF14.1160 Enolase 2.05 BC, DC, AP
LmjF36.2030 Chaperonin Hsp60, mitochondrial precursor 2.03 AP
LmjF23.1220 T-complex protein 1, gamma subunit, putative 2.00 AP
LmjF05.0350 Trypanothione reductase 1.99 GLY
LmjF36.2020 Chaperonin Hsp60, mitochondrial precursor 1.98 AP
LmjF36.1630 Clathrin heavy chain, putative 1.98 BC, AP
LmjF16.0540 Aspartate carbamoyltransferase, putative 1.95 GLY
LmjF27.2000 Hypothetical protein, conserved 1.90 GLY
LmjF31.1070 Biotin/lipoate protein ligase-like protein 1.89 AP
LmjF26.1240 Heat shock protein 70-related protein 1.86 BC, DC, AP
LmjF04.0960 Adenylate kinase, putative 1.77 GLY
LmjF27.1260 T-complex protein 1, beta subunit, putative 1.76 AP
LmjF30.3240 Glutamyl-tRNA synthetase, putative 1.74 GLY
LmjF21.0810 Methionyl-tRNA synthetase, putative 1.74 GLY
LmjF36.3210 14-3-3 Protein-like protein 1.74 DC, AP
LmjF33.2540 Carboxypeptidase, putative, metallo-peptidase 1.73 GLY
  1. a The Mascot algorithm {2008 609/id} was used to identify the protein names and the GeneDB accession numbers [29]. Microvesicles: BC, B-cell lymphocyte exosome [38,62]; DC, dendritic cell exosome [24]; AP, adipocyte exosome (adiposome) [39]; and GLY, leishmania glycosome [42]. CA, cell associated; Cm, conditioned medium; Hsp, heat shock protein.