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Table 3 Amino acids significantly preferred (-) or avoided (+) at 3' (top rows) and 5' (bottom rows) exon ends of C. neoformans compared to human

From: Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Amino acids*†

 

A

C

D

E

F

G

H

I

K

L4

L2

M

N

P

Q

R4

R2

S4

S2

T

V

W

Y

Species (number of exons)

+3

 

-7

 

-3

  

-2

-1

 

-5

 

-6

+2

 

+1

-4

 

+4

    

Human (178,438): 3'

 

-6

 

+1

-2

+4

-7

-1

+3

-3

    

+6

-5

+2

 

+5

   

-4

C. neoformans (28,446): 3'

+2

  

-4

-5

 

+7

-3

-1

 

-2

-8

-6

+1

+4

+3

-7

 

+5

+6

   

Human (178438): 5'

 

-9

  

-5

-7

 

-3

  

-1

-6

 

+2

 

+3

-4

+1

  

-8

-10

-2

C. neoformans (28,446): 5'

  1. *Indices signify rank order of slope coefficients, separately for negative and positive trends. †L2, R2, S2 and L4, R4, S4 signify the two-fold and four-fold degenerate blocks of leucine, arginine, and serine, respectively.