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Table 1 Amino acids significantly preferred (-) or avoided (+) at 3' ends of exons across species

From: Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Amino acids*†  
A C D E F G H I K L4 L2 M N P Q R4 R2 S4 S2 T V W Y Species (number of exons)
+3   -7   -3    -2 -1   -5   -6 +2   +1 -4   +4      Human (178,438)
+3   -6   -3    -2 -1   -5   -4 +1   +2 -7 +5 +4      Mouse (126,268)
   -4   -5 +3   -1 -2     -6 +2   +1 -3     +4    D. rerio (41,264)
    +4 -1 +3 -6 -2   +5    -3    +1 -4 +2 -5      C. elegans (79,958)
   -6 +3 -2 +4 -8 -3   +5 -5   -1 +6   +2 -7 +1 -4      C. briggsae (74,178)
        -1    -3   -2 +2   +1 -4        A. gambiae (7,930)
     -2 +1   -1    -3     +2          D. melanogaster (48,933)
     -2 +1 -5 -1   -4 +5    +3   +2    +6   +4   -3 A. mellifera (45,426)
      +2   -2   -1       -3 +3     +1    A. thaliana (109,900)
                        S. pombe (2,403)
           -1              S. cerevisiae (417)
  1. *Indices signify rank order of slope coefficients, separately for negative and positive trends. L2, R2, S2 and L4, R4, S4 signify the two-fold and four-fold degenerate blocks of leucine, arginine, and serine, respectively. S. cerevisiae terminal exons were retained given the small number of genes with more than one intron (eight).