Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle

Yanay, Chava; Morpurgo, Noa; Linial, Michal

doi:10.1186/gb-2008-9-2-r27

Table 1 Presynaptic protein prototypes

From: Evolution of insect proteomes: insights into synapse organization and synaptic vesicle life cycle

Number	Gene	Name	S	M
1	ADD2	β-Adducin	D
2	AMPH	Amphiphysin 1	D
3	AP2A1	AP-2 α-adaptin	A
4	AP3D1	AP-3 δ-adaptor	A
5	APBA1	Mint1	C
6	APBA2	Adapter protein X11β	B	*
7	ARF1	ARF 1	A
8	ARF6	ARF 6	A
9	ARFGEF2	ARF-GEF 2	B	*
10	ARFIP2	Arfaptin	B
11	ATP6V0C	ATPase 16 kDa	A
12	BAIAP3	Bai1-associated 3	D	*
13	BET1	Bet 1 homolog	B
14	BIN1	Bridging integrator 1	D
15	BLOC1S1	Lysosome BLOC1	B	*
16	BSN	Bassoon	E	*
17	CACNA1A	CaV2.1	B
18	CADPS	Caps	C	*
19	CALM2	Calmodulin	A
20	CASK	Lin-2 homolog	B
21	CLTC	Clathrin heavy chain	A
22	CNO	Cappuccino	D	*
23	CNTNAP1	Neurexin 4	D
24	CPLX2	Complexin 2	C
25	DLG1	SAP 97	B
26	DNAJC5	HSP40 homologue	B
27	DNM1	Dynamin 1	A
28	DOC2B	Double C2	C
29	EHD1	Testilin	A
30	EPN1	Epsin-1	C
31	EPS15	EGF substrate 15	D
32	ERC1	Rab6 interact CAST	D
33	EXOC6	Exocyst 6	C
34	EXPH5	Slp homolog	E	*
35	FLJ20366	Syntabulin	E	*
36	SNAP29	SNAP 29	D
37	GAP43	GAP 43	E	*
38	GDI2	Rab GDI 2	B
39	GMRP	P-selectin	D
40	GOPC	CFTR-associated ligand	C	*
41	GOSR2	Membrin	C
42	HGS	Hepatocyte TK subs	C
43	ITSN2	Intersectin	D
44	KIF1A	Kinesin family 1	B
45	LAMP1	Lysosomal 1	D
46	LIN7A	Mals-1	A
47	LPHN1	α-Latrotoxin receptor	D	*
48	MSS4	Rabif	C	*
49	MUTED	Muted	D	*
50	MYRIP	Rab-Myosin 7A	E	*
51	NET2	Tetraspanin-12	C
52	NLGN2	Neuroligin-2	D
53	NRXN1	Neurexin 1	D
54	NSF	NEM-sensitive fusion	B
55	PACSIN1	PKC and CK substrate	C	*
56	PCLO	Piccolo	D	*
57	PICALM	PI-binding clathrin	C
58	PIK4CA	P I4-kinase α	C
59	PIP5K1C	PI-4P 5-kinase 1γ	B
60	PLDN	Pallidin	D	*
61	PPFIA3	Liprin α 3	B
62	PSCD1	Cytohesin-1	A
63	PSCD2	Arno 2	B
64	RAB27A	Rab27A	B
65	RAB3A	Rab3A	A
66	RAB3GAP	Rab3 GTPase	D	*
67	RAB3IL1	Rabin 3	C	*
68	RAB6IP1	Rab6 interacting 1	C
69	RABAC1	YIP3 homolog	C
70	RABGAP1	Rab GTPase	C	*
71	RALA	Ral	A
72	RAPGEF4	Rap GEF 4	C
73	SEC22B	Sec22-like	B
74	RILP	Rab-interact	E	*
75	RIMBP2	RimS binding	D
76	RIMS1	Rims	D
77	RPH3A	Rabphilin 3A	C
78	SALF	Stoned B	D
79	SCAMP1	SCAMP37	C
80	SCIN	Scinderin	C	*
81	SEPT5	Septin 5	B
82	SH3GL1	Endophilin	C
83	SIPA1L1	Signal-proliferation 1	D
84	SLC17A7	VgluT1	C
85	SNAP25	SNAP-25	B
86	SNAP91	AP180	D
87	SNAPA	SNAP	B
88	SNAPAP	Snapin	C	*
89	SNIP	Snip	D	*
90	SNPH	Syntaphilin	E	*
91	SNX9	Sorting nexin	D	*
92	STX1A	Syntaxin	A
93	STXBP1	n-Sec	B
94	STXBP5	Tomosyn	C
95	STXBP6	Amisyn	E	*
96	SV2A	SV glycoprotein 1	D
97	SYBL1	Synaptobrevin-like	B
98	SYN	Synapsin	C
99	SYNGR1	Synaptogyrin	C	*
100	SYNJ1	Synaptojanin	C
101	SYNPR	Synaptoporin	E	*
102	SYP	Synaptophysin	E	*
103	SYT1	Synaptotagmin	B
104	SYT5	Synaptotagmin	B
105	SYT9	Synaptotagmin	C	*
106	SYTL4	Granulophilin	C	*
107	SYTL5	Synaptotagmin-like 5	D	*
108	TMEM163	synaptic vesicle31	E
109	TRAPPC1	Bet5 homolog	C
110	TRAPPC4	Sybindin	B
111	TXLNA	α-Taxilin	C	*
112	UNC13B	Munc-13	B	*
113	UNC13D	Unc-13 homolog	D
114	VAMP2	VAMP	A
115	VAPA	VAP33	C
116	VAT1	VAT-1	C	*
117	VPS18	Vacuolar sorting 18	D
118	VPS33B	Vps-33B	D
119	VTI1B	Vti1	D
120	YWHAQ	14-3-3 protein	A

The 120 presynaptic representatives from human (PS120) are indicated by their official gene names. Sequence conservation between human and insect proteomes is indicated by A to E. Sequence similarity index (S) is divided into five levels marked: A = >75%, B = >65%, C = >50%, D = >35%, and E = <34%. In the 'M' columns, an asterisk indicates that the gene is absent from the public protein databases. Detailed information on PS120 is provided in Additional data files 2a,2b.

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