Figure 4

Evolution conservation among components of synaptic complexes. Conservation is measured by sequence identity (y-axis [%]) between human and five species: mouse (Mus musculus; dark blue), chicken (Gallus gallus; green) frog (Xenopus laevis; gray), zebrafish (Danio rerio; orange), and fly (Drosophila melanogaster; light blue). Data are sorted according to human-fly conservation. The conservation of each component in the complexes is shown. Shown are findings regarding the synaptic complexes that are associated with functional organization of the postsynaptic membrane: exocyst (EXOC; eight proteins; see Figure 2a), coatomer protein (COP)-1 (nine proteins; see Figure 3a), biogenesis of lysosome-related organelles complex (BLOC)-1 (eight proteins; Figure 2b); peroxisome biogenesis (PEX; 14 proteins); dystrophin glycoprotein complex (DGC; 11 proteins); and metabotropic glutamate receptor (mGC; 12 proteins). Note that the conservation range for fly proteins of the DGC and mGC spreads on a broad range, and for these complexes the conservation along the evolution tree is poorly coordinated.