Figure 2

Exocyst protein interaction network in human and insects. (a) The subunits of mammalian exocyst (EXOC1 to EXOC8) and their yeast homologs (in parenthesis) are indicated. The percent of identity (I) and similarity (S) for human and the fly is shown. For mosquito, honeybee and beetle, the percentage identity and similarity (within each cell on top and bottom, respectively) relative to the D. malenogaster sequence are shown. Protein length is within 5% deviation between insect to their cognate human homolog. Dark blue background indicates similarity level above 75%, light blue indicates similarity above 65%, and white marks indicate similarity level below 64%. Gray background indicates that a homolog is missing. (b) Protein-protein interaction graph according to STRING tool (see Materials and methods). A tight interaction network extends from the exocyst to other partners (circled in blue) of small GTPase, RalA, and septin. aa, amino acids.