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Table 2 Genotype ratios of offspring at weaning following heterozygous intercrosses

From: A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development

  Observed Expected if semidominant, homozygous viable Expected if semidominant, homozygous lethal
MommeD7    
   Heterozygote* 65   60
   Wild type 25   30
MommeD8    
   Homozygote* 14 27.5  
   Heterozygote* 56 55  
   Wild type 40 27.5  
MommeD9    
   Heterozygote* 31   37.3
   Wild type 25   18.7
MommeD10    
   Homozygote* 14 77.25  
   Heterozygote* 187 154.5  
   Wild type 108 77.25  
  1. Offspring were classified as wild type, heterozygous or homozygous based on their GFP expression profiles. p-values: MommeD7, not significant; MommeD8, p < 0.005; MommeD9, not significant; MommeD10, p < 0.0001. *Progeny testing of mice classified based on GFP expression was carried out in a number of cases: 5 for MommeD7-/+, 11 for MommeD8-/-, 16 for MommeD8-/+, 8 for MommeD9-/+, 6 for MommeD10-/- and 11 for MommeD10-/+. In all cases the genotype was as expected. Presumed genotype was confirmed by genotyping for 8 MommeD10-/- and 79 MommeD10-/+ mice.