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Table 1 The 27 GO CAN-processes prioritized by the BN model or the HG enrichment test based on cancer genes from the 'cancer-gene census' database

From: Prioritizing functional modules mediating genetic perturbations and their phenotypic effects: a global strategy

GO CAN-processes prioritized by the BN model

GO CAN-processes prioritized by the HG enrichment test

GO CAN-process

Total gene number

Cancer gene number

GO CAN-process

Total gene number

Cancer gene number

GO:0006366 transcription from RNA polymerase II promoter

541

52

GO:0050794 regulation of cellular process

3,958

205

GO:0045737 positive regulation of cyclin-dependent protein kinase activity

3

3

GO:0050789 regulation of biological process

4,256

209

GO:0045786 negative regulation of progression through cell cycle

203

41

GO:0065007 biological regulation

4,648

217

GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway

168

23

GO:0043283 biopolymer metabolic process

5,095

226

GO:0048268 clathrin cage assembly

4

2

GO:0000074 regulation of progression through cell cycle

325

53

GO:0000718 nucleotide-excision repair, DNA damage removal

21

7

GO:0051726 regulation of cell cycle

329

53

GO:0002903 negative regulation of B cell apoptosis

2

2

GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

2,501

145

GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process

3

2

GO:0031323 regulation of cellular metabolic process

2,703

151

GO:0010225 response to UV-C

2

2

GO:0006350 transcription

2,540

145

GO:0006310 DNA recombination

92

13

GO:0019222 regulation of metabolic process

2,832

154

GO:0016571 histone methylation

6

2

GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

3,771

181

GO:0060070 Wnt receptor signaling pathway through beta-catenin

5

2

GO:0045449 regulation of transcription

2,448

140

GO:0016573 histone acetylation

10

4

GO:0006351 transcription, DNA-dependent

2,360

136

GO:0045429 positive regulation of nitric oxide biosynthetic process

5

3

GO:0006355 regulation of transcription, DNA-dependent

2,302

134

GO:0006298 mismatch repair

31

7

GO:0045786 negative regulation of progression through cell cycle

203

41

GO:0009168 purine ribonucleoside monophosphate biosynthetic process

15

2

GO:0032774 RNA biosynthetic process

2,364

136

GO:0010332 response to gamma radiation

3

2

GO:0043170 macromolecule metabolic process

6,647

244

GO:0045661 regulation of myoblast differentiation

6

2

GO:0022402 cell cycle process

606

61

GO:0030101 natural killer cell activation

15

3

GO:0016070 RNA metabolic process

2,896

143

GO:0046902 regulation of mitochondrial membrane permeability

5

2

GO:0007049 cell cycle

761

67

GO:0051353 positive regulation of oxidoreductase activity

5

2

GO:0048523 negative regulation of cellular process

917

73

GO:0051898 negative regulation of protein kinase B signaling cascade

2

2

GO:0048519 negative regulation of biological process

958

73

GO:0000910 cytokinesis

28

4

GO:0044238 primary metabolic process

7,595

254

GO:0000075 cell cycle checkpoint

58

14

GO:0048522 positive regulation of cellular process

754

63

GO:0001952 regulation of cell-matrix adhesion

9

6

GO:0006366 transcription from RNA polymerase II promoter

541

52

GO:0042593 glucose homeostasis

11

2

GO:0048518 positive regulation of biological process

840

65

GO:0014065 phosphoinositide 3-kinase cascade

5

3

GO:0009719 response to endogenous stimulus

400

44

Median number

6

3

Median number

2,364

136