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Figure 4 | Genome Biology

Figure 4

From: Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells

Figure 4

Enhancer/repressor assay of CNCSs. (a, b) Boxplots showing the distribution of the luciferase activity for each subset of sequences in 293T (a) and Huh7 (b) cell lines. The proportion of putative regulatory elements of each subgroup is indicated at the bottom of both graphs. (c-f) Bar graphs showing the fold change of luciferase activity compared to the control sequence set for 71 selected CNCSs (c, d), 23 CNCS overlapping transcription factor binding sites (TFBSs) (e, f), in 293T and Huh7 cell lines, respectively. Red lines show ± 2-fold change threshold. Asterisks denote statistically significant change (one-sample t-test).

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