Figure 2

Chromatin Central proteomic environment in S. cerevisiae. Individual protein complexes are boxed; TAP-tagged subunits are indicated with asterisks. The proteomic hyperlinks (proteins shared between the individual complexes) are shown between the complexes in grey diamonds. The hyperlink from Tra1 to the SAGA/SLIK complex is designated with a dashed line/filled arrow because it was not identified in this work, but inferred from published evidence. Gene names designated with a minus (-) symbol indicate that their TAP tagging/immunoaffinity purification failed. Several relatively abundant (A-index > 1.75) pair-wise interactors, also identified in proteome-wide screens [101, 102], are mapped onto the scheme (dashed line/unfilled arrow). Set3C complex was previously characterized by TAP-tagging method in [10].