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Figure 1 | Genome Biology

Figure 1

From: Genome adaptation to chemical stress: clues from comparative transcriptomics in Saccharomyces cerevisiae and Candida glabrata

Figure 1

PCA analysis of the time-course responses of S. cerevisiae and C. glabrata transcriptomes to chemical stress. Microarray results were analyzed by PCA. The (a) S. cerevisiae and (b) C. glabrata datasets were examined independently. The panels on the left show biplots of the PCA results. Points represent genes. The horizontal axes correspond to the first principal component (PC1), accounting for 78% of the total variance in S. cerevisiae and 82% in C. glabrata. Vertical axes correspond to the second principal component (PC2), accounting for 13% of the total variance in S. cerevisiae and 8% in C. glabrata. Initial time vectors are shown in blue and genes significantly up- and down-regulated are shown in red and green, respectively. The panels on the right show the variability accounted for by each component. Each panel also shows the loadings of initial time vectors on the first principal component (PC1). In both species, the first two principal components account for more than 90% of the global variance in the microarray datasets. (c) Graphical representation of the relationships between the time points in the two species studied here. In each species, the time point expression measurements are represented by nodes and arrows connect experiments with the highest correlation values (Additional data file 1) for cross-species correlation values between different time points).

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