Architecture, resources, network-centric communication. The complete ArrayPlex environment is composed of the combination of the ArrayPlex application server and the many genomic resources and analytical toolsets that it installs, manages, and provides. The ArrayPlex server installs genomic annotations, ontological assignments, and genome sequence for supported organisms. Additionally, toolsets providing genomic sequence extraction, BLAST, sequence search, sequence discovery, and multi-sequence alignment are provided. Both the ArrayPlex client and command-line modules network-access these genome resources and analytical toolsets through the documented ArrayPlex API.