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Table 1 FBLs identified in the TRN of Escherichia coli

From: Functional architecture of Escherichia coli: new insights provided by a natural decomposition approach

Type of FBL Number of genes Genes Interactions Are genes in the same operon?
+ 2 arcA fnr - - No
- 2 arcA fnr - + No
- 2 gadX hns + - No
+ 2 gadX rpoS + + No
- 2 gutM srlR + - Yes
- 2 lexA rpoD - + No
- 2 marA marR + - Yes
- 2 marA rob - + No
+ 2 rpoD rpoH + + No
+ 3 crp rpoH rpoD + + + No
- 3 crp rpoH rpoD - + + No
- 3 cytR rpoH rpoD - + + No
+ 3 gadE gadX rpoS + + + No
+ 3 marA rob marR - + - No
+ 3 rpoD rpoN rpoH + + + No
- 4 cpxR rpoE rpoH rpoD - + + + No
- 4 crp cytR rpoH rpoD + - + + No
- 5 IHF fis hns gadX rpoS + + - + + No
- 5 argP dnaA rpoH rpoD phoB + - + + + No
- 5 cpxR rpoE rpoN rpoH rpoD - + + + + No
  1. Eighty percent of the total FBLs involve, at least, one global TF. The longest FBL comprises five TFs. Only two FBLs have genes encoded in the same operon, contrary to what was previously reported by Ma et al. [10], thus suggesting that these FBLs work as uncoupled systems. In addition, seven positive FBLs were identified, which potentially could give rise to multistability.