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Table 2 Association of MYCN/c-MYC target gene clusters with overall survival in primary neuroblastomas (n = 251)

From: Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Cluster Number of genes Rank OS* p-value OS Rank OS with CV* p-value OS with CV
168 (I) 19 3 <0.0001 1 0.0004
140 (I) 38 4 <0.0001 2 0.0006
195 (I) 21 31 <0.0001 12 0.0060
308 (II) 33 18 <0.0001 26 0.0161
280 (II) 32 29 <0.0001 37 0.0232
336 (II) 26 51 <0.0001 45 0.0280
  1. *Rank of all 504 clusters tested for association with overall survival (OS) using the Global test without and with adjustment for co-variables (CV; amplified MYCN, stages 1, 2, 3, 4s versus 4, age at diagnosis ≥1.5 years). p-value from Global test adjusted for multiple testing. In the Cluster column, I or II gives the cluster group as defined by the SOM analysis using SH-EPMYCNcells.