Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

Table 2 Association of MYCN/c-MYC target gene clusters with overall survival in primary neuroblastomas (n = 251)

Cluster	Number of genes	Rank OS*	p-value OS^†	Rank OS with CV*	p-value OS with CV^†
168 (I)	19	3	<0.0001	1	0.0004
140 (I)	38	4	<0.0001	2	0.0006
195 (I)	21	31	<0.0001	12	0.0060
308 (II)	33	18	<0.0001	26	0.0161
280 (II)	32	29	<0.0001	37	0.0232
336 (II)	26	51	<0.0001	45	0.0280

*Rank of all 504 clusters tested for association with overall survival (OS) using the Global test without and with adjustment for co-variables (CV; amplified MYCN, stages 1, 2, 3, 4s versus 4, age at diagnosis ≥1.5 years). ^†p-value from Global test adjusted for multiple testing. In the Cluster column, I or II gives the cluster group as defined by the SOM analysis using SH-EP^MYCNcells.

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