Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases

Table 1 Top Gene Ontology biological processes in each module

Module	Activity	Ease score
Module 1	Protein biosynthesis	7.14E-06
	Cell development	2.37E-05
	Cell differentiation	4.88E-05
	Macromolecule biosynthesis	8.56E-05
	Cellular nerve ensheathment	1.11E-04
	Neuron development	2.22E-04
	Regulation of action potential	4.37E-04
Module 2	Response to other organism	0.004
	Immune response	0.014
	Defense response	0.020
	Response to stress	0.029
	Protein kinase cascade	0.030
	Integrin-mediated signalling pathway	0.030
	Myeloid cell differentiation	0.040
	JAK-STAT cascade	0.042
Module 3	Homophilic cell adhesion	2.58E-11
	Cell-cell adhesion	2.74E-09
	Nervous system development	3.44E-09
	Ion transport	0.007
	Gamma-aminobutyric acid signalling pathway	0.009
	Secretory pathway	0.019
	Small GTPase mediated signal transduction	0.028
	Sodium ion transport	0.036
Module 4	Cellular physiological process	6.91E-05
	Transcription from RNA polymerase II promoter	0.008
	Protein transport	0.014
	Post-chaperonin tubulin folding pathway	0.019
	Ubiquitin cycle	0.037
Module 5	Negative regulation of metabolism	0.011
	Actin filament depolymerization	0.025
	Barbed-end actin filament capping	0.025
	Negative regulation of actin filament depolymerization	0.025
	Negative regulation of protein metabolism	0.025
Module 6	Protein transport	0.008
	Cell organization and biogenesis	0.011
	Membrane fusion	0.028
	RNA processing	0.029
	RNA splicing	0.042

Statistically significant (p < 0.05) biological processes present in each of the six modules of the co-expression network.

ISSN: 1474-760X