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Table 2 Over-representation of ESR, DDR and CC genes in cdc13-1 dataset and QT clusters

From: A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2in chromosome end protection

Gene set (size)

ESR

DDR

CC

QT1 (242)

33%

57%

35%

QT2 (160)

28%

51%

24%

QT3 (77)

51%

74%

49%

QT4 (28)

57%

71%

39%

QT5 (23)

22%

61%

26%

QT6 (21)

0%

57%

81%

QT7 (9)

44%

78%

11%

QT8 (8)

38%

63%

25%

QT9 (5)

0%

100%

100%

QT10 (8)

0%

25%

63%

QT11 (6)

50%

67%

50%

QT12 (8)

0%

38%

100%

QT13 (7)

0%

71%

100%

Altered in cdc13-1 (647)

41% ( P ≤ 10e-15)

40% ( P ≤ 10e-15)

31% ( P ≤ 10e-15)

S. cerevisiae genome

14%

25%

22%

  1. Table showing percentage of genes in the S. cerevisiae genome, cdc13-1 dataset and QT clusters 1-13 that have been shown to be differentially expressed in response to environmental stress, DNA damage, and cell cycle progression. Hypergeometric tests were used to determine whether each class of gene was over-represented in the QT clusters. Percent values shown in bold are statistically over-represented. Gene proportions in the cdc13-1 dataset were compared to expression across the S. cerevisiae genome, while gene proportions in each QT set were compared to proportions across the cdc13-1 experiment. ESR, all genes involved in the environmental stress response (868) [24]; DDR, all genes that are altered in response to either methyl methanesulfonate, ionizing radiation or a single HO cut (1,529) [27, 28]; CC, all genes known to be cell cycle regulated (1,271) [30]