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Table 3 Pax2/8 over-expression effect on predicted downstream targets

From: Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools

Clone

Expression in the otic vesicle

Effect upon pax2 misexpression (%)*

n

brn2

Yes

Repression: 40

28

ccdc102a

Yes

Activation: 23

34

metrnl

Yes

Activation: 35

20

sec31l

Yes

Activation: 44

25

cldn7

Yes

Activation: 28

51

  1. *Injected embryos were heat treated during nine somites. Three hours later, GFP positive embryos were fixed.
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Genome Biology

ISSN: 1474-760X

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