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Figure 1 | Genome Biology

Figure 1

From: Translation controlled

Figure 1

Transfer RNA hybrid states. The figure depicts two cryo-electron-microscopic reconstructions of the ribosome, one (a) showing two tRNAs (green and magenta) in the canonical A (A/A) and P (P/P) positions, the other (b) showing them in the hybrid A/P and P/E positions relative to the 50S subunit (blue) with the 30S subunit (yellow; see inset) computationally removed. tRNA reconfiguration accompanies a spontaneous rotation of the small subunit with respect to the large subunit (ratchet motion). The repositioning of the tRNAs accompanies a change in their immediate environment that is caused by the rotation of the small subunit. Figure courtesy of Xabier Agirrezabala and Joachim Frank, with permission from Quarterly Reviews in Biophysics.

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