Figure 3

Data integration steps for interacting residue prediction. Schematic outline of data integration for the prediction of interacting residues. Mutations from OMIM and UniProt for which a residue in a homologous structure is involved in an interaction are selected. This set is restricted further by searching for homologous proteins with known interactions, taken from a range of protein interaction databases. We require that the the homologous interacting proteins contain the same pair of Pfam domains that was observed in the structural template. This results in a set of 1,428 interaction related mutations.