Figure 1From: Protein interactions in human genetic diseasesConservation difference between wild-type and mutated residues. Histogram of conservation of wild-type and mutated residues. Triangles denote the residue-conservation frequency of all residues in disease protein regions that map to an iPfam domain. Circles show the conservation of the pathogenic alleles (see Materials and methods). Trendlines are added to delineate normal distributions.Back to article page