Table 5 Selected annotations for the conserved transcriptomic signatures identified for the cell types studied
Cell type* | Annotation | Genes |
|---|---|---|
Myeloid cells | Defense response/response to pest, pathogen or parasite/inflammatory response | C5ar1, Sod2, Fcgr3, Tlr2, Ccr1, Ifrd1, Csf3r, Clec7a, Bst1, Ifit1, Clec4e, Tlr4, Clec4d, Cd14, Cebpb, Hp |
| Â | Response to bacteria or fungi/pattern recognition receptor activity/C-type lectin | SLC11A1, TLR2, TLR4, CLEC7A, Clec4e, Clec4d |
| Â | H_tollpathway: Toll-like receptor pathway | CD14, TLR2, TLR4 |
|  | Regulation of cytokine biosynthesis/positive regulation of TNF-α or IL-6 biosynthesis | Fcgr3, Tlr2, Tlr4, Cebpb, Clec7a |
| Â | Macrophage activation/mast cell activation/neutrophil chemotaxis | CD93, TLR4, Fcgr3, Csf3r |
Pan-DC | Binding | ETV6, PRKRA, FLT3, SCARB1, TRIT1, BAHCC1, SH3TC1 |
cDC | Nucleobase, nucleoside, nucleotide and nucleic acid metabolism | NAV1, BTBD4, CIITA, SNFT |
| Â | Molecular function unknown | Btbd4, Avpi1, Arhgap22 |
pDC | Transcription cofactor activity | Maged1, Bcl11a, Tcf4 |
| Â | Integral to membrane | TLR7, EPHA2, TMEPAI, SCARB2, ATP13A2, ALG2, CYBASC3, TM7SF2, GPM6B, PTPRS |
| Â | Cellular component unknown | Maged1, Sh3bgr, Cybasc3, Alg2, Plac8 |
B cells | MMU04662: B cell receptor signaling pathway/B cell activation | Cr2, Cd79a, Cd79b, Cd72, Cd19, Blr1, Ms4a1 |
| Â | MMU04640: hematopoietic cell lineage | Cr2, Fcer2a, Ms4a1, Cd19 |
| Â | Defense response/response to pest, pathogen or parasite/humoral immune response | PAX5, POU2F2, CR2, MS4A1, CD72, CD19, POU2AF1, BLR1, CD79A, CD79B, FCER2 |
NK cells | MMU04650: natural killer cell mediated cytotoxicity/apotosis | Klrd1, Ifng, Ncr1, Fasl, Prf1, Prf1, Plekhf1 |
| Â | Defense response | IL18RAP, CTSW, IFNG, FASLG, CD160, NCR1, PRF1, KLRD1, CST7 |
Pan-T cells | HSA04660: T cell receptor signaling pathway/immunological synapse | CD3E, ICOS, PLCG1, LAT, CD3G, Trat1 |
| Â | Defense response/immune response | Cd5, Icos, Cd3e, Ubash3a, Lat, Trat1, Cd3g |
| Â | HSA04640: hematopoietic cell lineage | CD3E, CD3G, CD5 |
CD8 T cells | No annotations | - |
CD4 T cells | Defense response/immune response | Cd28, Icos, Cd5, Ctla4, Trat1 |
| Â | M_ctla4pathway: the co-stimulatory signal during T-cell activation | Cd28, Icos, Ctla4 |
Lymphocytes | Immune response | BCL2, LAX1, ETS1 |
Myeloid, B, DC | Antigen presentation, exogenous antigen via MHC class II | H2-Eb1, H2-DMb2, H2-DMb1, Cd74 |
| Â | HSA04612: antigen processing and presentation | HLA-DRB1, CIITA, CD74, HLA-DMB |
| Â | Defense response/immune response | H2-Eb1, H2-DMb2, H2-DMb1, Bcl11a, Cd74 |
Non-DC | Phosphoric ester hydrolase activity | LCK, PDE3B |