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Table 11 Comparison of the transcriptome of mouse GM-CSF BM-derived DCs to that of spleen DCs

From: Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling

    Ratio to monocytes
Probe set ID Name Mono Mono(2) BM-MΦ BM-DC pDC CD8 DC CD11b DC
Myeloid signature genes          
1420804_s_at Clec4d 4,934 0.65 0.49 0.75 0.41 - - -
1420330_at Clec4e 5,511 0.11 0.22 0.23 0.11 - - -
1450808_at Fpr1 119 1.91 - 5.55 2.41 - - -
1452001_at Nfe2 139 1.44 - - 3.31 - - -
1450919_at Mpp1 1,888 0.15 2.05 1.75 0.52 0.23 0.09 0.07
1419609_at Ccr1 403 1.27 4.04 0.53 3.98 0.2 - -
1417061_at Slc40a1 2,588 0.68 - 0.56 0.07 0.01 0.01 0.02
1448756_at S100a9 8,664 1.2 - 0.01 0.99 0 0 -
1417268_at Cd14 6,745 0.1 0.3 0.6 0.19 0.02 0.01 0.01
1418163_at Tlr4 464 0.1 0.36 0.93 0.66 - 0.07 0.06
1448620_at Fcgr3 1,471 2.02 3.56 2.15 2.46 - 0.02 0.07
1422953_at Fpr-rs2 839 2.04 0.12 0.85 1.58 - - 0.05
1419132_at Tlr2 1,763 0.11 0.42 0.24 0.48 0.04 0.1 0.14
1417566_at Abhd5 170 0.19 0.72 0.86 2.2 0.18 0.45 0.25
1415814_at Atp6v1b2 1,556 0.22 2.75 1.57 1.43 0.18 0.27 0.24
1427327_at Pilra 434 1.53 0.16 0.47 2.29 0.1 - 0.21
1418888_a_at Sepx1 4,416 0.48 0.34 0.31 0.56 0.03 0.04 0.05
1438928_x_at Ninj1 5,574 0.03 1.3 0.46 0.36 0.03 0.02 0.02
1448881_at Hp 400 3.19 0.14 0.06 3.09 - - -
1449453_at Bst1 340 1.08 4.97 0.58 1.61 0.21 0.51 -
1419394_s_at S100a8 10,190 1.37 0.01 0.01 0.66 - 0 -
1437200_at Fcho2 311 1.09 1.32 1.06 0.76 0.28 0.2 0.33
1418806_at Csf3r 2,598 0.2 0.14 0.19 0.11 - - 0.03
1439902_at C5ar1 317 8.21 0.19 1.63 0.37 - - -
1456046_at Cd93 1,559 0.1 0.49 1.18 0.33 0.02 - -
1418901_at Cebpb 3,797 0.14 0.7 0.22 0.42 0.02 0.01 0.02
1420699_at Clec7a 2,748 0.83 2.62 0.44 1.71 0.08 0.06 0.54
Pan-DC signature genes          
1419538_at Flt3 51 0.74 - - 0.7 16.2 25.32 17.78
1427619_a_at Sh3tc1 - >1.1 >6.8 >2.8 >4.9 >5.2 >6.5 >4.6
1424489_a_at Trit1 54 7.28 0.44 0.76 1.23 9.03 11.53 8.63
1428744_s_at Bri3bp 161 0.84 0.6 1.44 3.28 6.09 7.24 5.98
1448923_at Prkra 72 1.28 0.77 2.89 2.57 4.45 7.88 3.63
1434880_at Etv6 140 5.39 1.52 0.74 1.75 5.79 6.02 7.78
1416108_a_at Tmed3 154 0.81 3.74 2.63 4.65 10.17 4.48 3
1436633_at Bahcc1 41 1.77 - 0.83 - 1.8 3.88 2.35
1437378_x_at Scarb1 97 5.02 1.25 2.61 3.17 7.41 8.27 4.05
cDC signature genes          
1435108_at Arhgap22 63 - - 2.37 0.57 0.59 10.65 4.43
1429168_at Btbd4 129 0.19 0.27 - 0.47 0.81 3.89 3.8
1425294_at Slamf8 146 1.06 39.89 1.83 1.77 0.39 8.48 5.27
1453076_at 9130211I03Rik 36 1.61 2.85 1.03 13.11 0.62 30.94 25.64
1436907_at Nav1 102 1.59 0.74 2.63 1.96 1.21 6.08 13.14
1421210_at C2ta 125 0.17 1.79 0.19 0.93 1.46 5.94 5.43
1423122_at Avpi1 150 0.32 - 0.2 0.86 0.61 2.47 7.62
1416627_at Spint1 - >1.5 >1.1 - >22.9 >1.6 >25.7 >30.6
1450667_a_at Cs 396 2.47 0.9 1.19 3.54 2.83 4.64 4.5
APC signature genes          
1419744_at H2-DMb2 451 0.12 0.1 0.08 1.47 0.45 0.48 1.69
1443687_x_at H2-DMb1 547 0.56 0.13 0.11 1.56 1.06 0.82 3.13
1434955_at March1 80 32.64 0.83 1.51 3.48 3.73 13.4 8.57
1448143_at Aldh2 867 0.47 2.14 2.07 1.32 0.95 0.65 0.45
1419406_a_at Bcl11a 60 1.47 0.34 - 0.71 20.41 7.63 9.19
1422755_at Btk 416 0.56 0.76 1.3 1.15 0.88 1.45 1.17
1418365_at Ctsh 1,393 0.81 3.9 2.19 2.15 3.69 1.24 2.16
1417025_at H2-Eb1 6,385 0.13 0.39 0.04 0.8 0.9 1.31 1.33
1425519_a_at Cd74 8,377 0.36 0.95 0.2 0.9 0.83 0.97 0.98
1417868_a_at Ctsz 7,061 0.05 1.16 0.95 0.85 0.5 0.3 0.49
1423393_at Clic4 2,807 0.07 2.04 0.84 0.57 0.69 0.72 0.67
1430570_at Kynu 31 1.23 - - 3.21 12.87 5.16 11.56
1435745_at 5031439G07Rik 356 0.95 0.73 2.76 2.51 3.23 3.14 4.28
1458299_s_at Nfkbie 767 0.4 0.62 0.1 0.44 1.25 0.65 1.27
1423768_at Unc93b1 663 0.1 2.27 2.69 1.46 1.2 0.93 0.91
Non-DC signature genes          
1424375_s_at Gimap4 362 0.14 0.29 - 0.1 0.11 - 0.11
1424380_at Vps37b 313 0.44 0.46 0.45 0.26 0.28 0.28 0.27
1425396_a_at Lck 118 - 0.57 0.2 0.32 0.21 - 0.17
1433694_at Pde3b 352 0.69 0.15 0.16 0.42 - 0.65 0.35
  1. *Average expression across replicates. Genes for which expression between mouse bone-marrow derived GM-CSF DCs (BM-DCs) and spleen DCs or spleen cDCs varies more than two-fold are shown in bold. BM-MΦ, mouse bone marrow-derived M-CSF macrophages; MΦ, peritoneal mouse macrophages; mono, mouse spleen monocytes from the SB laboratory; mono(2), mouse spleen monocytes from the BP laboratory, as listed in Table 1.