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Figure 1 | Genome Biology

Figure 1

From: Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus

Figure 1

Molecular structures of the NS3-4A serine protease inhibitors VX-950 (telaprevir) and SCH 503034 (boceprevir) as well as of the co-crystallized protease ligands CPX and SCH 446211. The P1 to P4 and P'1 to P'2 groups are numbered according to the nomenclature of Schechter and Berger [61]. Residues surrounding a cleavage site are designated from the amino- to carboxyl-terminus, that is, P4-P3-P2-P1 P'1-P'2-P'3-P'4, with the scissile bond between P1 and P'1. They are annotated only for SCH 446211.

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