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Table 2 Significant correlations between BMI and expression profiles of genes annotated with themes composing the GO Biological Process interaction modules in obese WAT

From: Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

EntrezGene gene ID Gene symbol Gene name Fold* Rs FDR Tissular fraction§
Module 1       
   1880 EBI2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) 1.63 0.62 0.00 SVF
   5788 PTPRC protein tyrosine phosphatase,receptor type,C 1.74 0.61 0.00 SVF
   1520 CTSS cathepsin S 1.53 0.54 0.00 SVF
   51107 APH1A anterior pharynx defective 1 homolog A 1.40 0.50 0.01 SVF
   1439 CSF2RB colony stimulating factor 2 receptor,beta,low-affinity (granulocyte-macrophage) 2.03 0.49 0.01 SVF
   3937 LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa) 1.87 0.49 0.01 SVF
   919 CD247 CD247 molecule 1.36 0.49 0.01 SVF
   3301 DNAJA1 DnaJ (Hsp40)homolog,subfamily A,member 1 1.46 0.48 0.02 SVF
   131566 DCBLD2 discoidin,CUB and LCCL domain containing 2 2.00 0.47 0.02 -
   9448 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 1.40 0.47 0.02 -
   3091 HIF1A hypoxia-inducible factor 1,alpha subunit (basic helix-loop-helix transcription factor) 1.32 0.46 0.02 SVF
   11183 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 1.35 0.44 0.03 A
   23678 SGK3 serum/glucocorticoid regulated kinase family,member 3 1.48 0.44 0.03 -
   667 DST dystonin 1.66 0.44 0.03 SVF
   10954 PDIA5 protein disulfide isomerase family A,member 5 1.34 0.43 0.03 -
   2113 ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 1.65 0.41 0.03 -
   8506 CNTNAP1 contactin associated protein 1 1.24 0.41 0.03 SVF
   10437 IFI30 interferon,gamma-inducible protein 30 2.35 0.40 0.04 SVF
   10095 ARPC1B actin related protein 2/3 complex,subunit 1B,41 kDa 1.74 0.39 0.04 SVF
Module 2       
   5256 PHKA2 phosphorylase kinase,alpha 2 0.67 -0.67 0.00 A
   3643 INSR insulin receptor 0.67 -0.66 0.00 -
   23604 DAPK2 death-associated protein kinase 2 0.44 -0.61 0.00 A
   1384 CRAT carnitine acetyltransferase 0.62 -0.61 0.00 A
   1968 EIF2S3 eukaryotic translation initiation factor 2,subunit 3 gamma,52 kDa 0.63 -0.58 0.00 -
   11000 SLC27A3 solute carrier family 27 (fatty acid transporter),member 3 0.76 -0.56 0.01 SVF
   10572 SIVA1 CD27-binding (Siva)protein 0.69 -0.54 0.01 A
   6158 RPL28 ribosomal protein L28 0.66 -0.53 0.01 SVF
   6206 RPS12 ribosomal protein S12 0.53 -0.52 0.01 SVF
   11224 RPL35 ribosomal protein L35 0.65 -0.51 0.01 SVF
   6187 RPS2 ribosomal protein S2 0.77 -0.51 0.01 -
   51069 MRPL2 mitochondrial ribosomal protein L2 0.59 -0.50 0.01 A
   93974 ATPIF1 ATPase inhibitory factor 1 0.79 -0.49 0.01 -
   134 ADORA1 adenosine A1 receptor 0.75 -0.48 0.01 A
   51023 MRPS18C mitochondrial ribosomal protein S18C 0.74 -0.48 0.01 A
   35 ACADS acyl-CoA dehydrogenase,C-2 to C-3 short chain 0.69 -0.48 0.01 A
   6227 RPS21 ribosomal protein S21 0.62 -0.48 0.02 SVF
   4694 NDUFA1 NADH dehydrogenase (ubiquinone)1 alpha subcomplex,1,7.5 kDa 0.86 -0.48 0.02 A
   1936 EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.75 -0.47 0.02 SVF
   3991 LIPE lipase,hormone-sensitive 0.76 -0.46 0.02 A
   10063 COX17 COX17 cytochrome c oxidase assembly homolog 0.71 -0.45 0.02 -
   5346 PLIN perilipin 0.71 -0.45 0.02 A
   27335 EIF3S12 eukaryotic translation initiation factor 3,subunit 12 0.73 -0.43 0.03 A
   84545 MRPL43 mitochondrial ribosomal protein L43 0.78 -0.43 0.03 A
   8613 PPAP2B phosphatidic acid phosphatase type 2B 0.50 -0.42 0.03 SVF
   1983 EIF5 eukaryotic translation initiation factor 5 0.76 -0.42 0.03 SVF
   1611 DAP death-associated protein 0.70 -0.40 0.04 SVF
   6166 RPL36AL ribosomal protein L36a-like 0.73 -0.40 0.04 -
   6152 RPL24 ribosomal protein L24 0.74 -0.40 0.04 SVF
   122970 ACOT4 acyl-CoA thioesterase 4 0.65 -0.40 0.04 A
   5255 PHKA1 phosphorylase kinase,alpha 1 0.81 -0.39 0.04 -
   6165 RPL35A ribosomal protein L35a 0.72 -0.39 0.04 SVF
  1. *Gene expression fold change in the obese versus lean condition. Spearman's correlation coefficients between gene expression profiles and the BMI of analyzed subjects. The q-values obtained by applying the Storey (2002) FDR method to adjust the p values computed with the Spearman's correlation test. §Genes expressed predominantly in one of the two main cellular fractions of the adipose tissue: mature adipocytes (A) or the stroma vascular fraction (SVF). Hyphens indicate genes for which no significantly predominant expression in one of the two main cellular fractions of the adipose tissue could be detected.