KEGG enriched themes and their interaction map, illustrating the transcriptomic signature of obese WAT. (a) The KEGG annotating categories showing a significant enrichment in genes up- or down-regulated in the WAT of obese subjects. (b) These categories were related to construct a functional interaction map after quantifying their proximity based on the expression similarity of their annotated genes. Continuous lines indicate the strongest interactions (that is, superior to the upper quartile of their distribution), while dashed lines depict medium strength interactions (that is, superior to the median of the distribution but inferior to its upper quartile). The enrichment in genes expressed preferentially in one of the two main cellular fractions of WAT, illustrated in a percentage scale (mature adipocytes in light gray versus SVF in black), was significantly different in the two modules (p value < 0.001).