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Table 1 Comparison of gene knockout strategies in rodents

From: Mutagenesis in rodents using the L1 retrotransposon

Criteria Retroviral ENU Retrotransposon
Disrupt genes completely Yes No Yes
Random mutation No Yes Yes
High frequency mutation Yes Yes Yes
Quickly map mutations Yes No Yes
Efficiently create knockout animals No Yes Yes
  1. ENU, N-ethyl-N-nitrosourea.